Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 1.00 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795715 | 1.00 | NOTUM (1.00) | NOTUMHSD17B3DRD2DRD4LMNA | |
| SCHEMBL5009163 | 0.87 | NOTUM (1.00) | NOTUMHSD17B3ALDH1A1CYP11B2 | |
| SCHEMBL4111792 | 0.85 | NOTUM (0.73) | NOTUMHSD17B3DRD2DRD4KMT2A | |
| SCHEMBL21425060 | 0.85 | NOTUM (0.73) | NOTUMHSD17B3DRD2DRD4KMT2A | |
| SCHEMBL16600474 | 0.83 | NOTUM (0.71) | NOTUMHSD17B3DRD2DRD4KMT2A | |
| SCHEMBL20348525 | 0.83 | NOTUM (0.70) | NOTUMHSD17B3DRD2DRD4LMNA | |
| SCHEMBL429841 | 0.81 | NOTUM (0.76) | NOTUMDRD2DRD4LMNAKMT2A | |
| SCHEMBL8141492 | 0.81 | NOTUM (0.69) | NOTUMHSD17B3DRD2LMNAPKM | |
| SCHEMBL8895360 | 0.81 | NOTUM (0.68) | NOTUMHSD17B3DRD2DRD4LMNA | |
| SCHEMBL11224906 | 0.81 | NOTUM (0.68) | NOTUMHSD17B3DRD2DRD4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230050653-A1 | ROCK INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2023-02-16 | — | — | US | disclosed |
| WO-2021093795-A1 | ROCK INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 武汉朗来科技发展有限公司 | 2021-05-20 | — | — | WO | disclosed |
| EP-2903615-B1 | 5-PYRIDIN-3-YL-2,3-DIHYDRO-1H-INDOLE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP11B2) INHIBITORS FOR THE TREATMENT OF HYPERTENSION | MERCK SHARP & DOHME (US) | 2021-04-07 | — | — | EP | disclosed |
| EP-2903615-B1 | 5-PYRIDIN-3-YL-2,3-DIHYDRO-1H-INDOLE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP11B2) INHIBITORS FOR THE TREATMENT OF HYPERTENSION | MERCK SHARP & DOHME (US) | 2021-04-07 | — | — | EP | disclosed |
| US-20180186755-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA INC (US) | 2018-07-05 | — | — | US | disclosed |
| US-9745282-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745282-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745282-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-08-29 | — | — | US | disclosed |
| US-9550750-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-01-24 | — | — | US | disclosed |
| US-9550750-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150225365-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | ELEXOPHARM GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
| US-20150225365-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | ELEXOPHARM GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
| EP-2903615-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITIORS RELATED APPLICATIONS | Merck Sharp & Dohme Corp. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014055595-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITIORS RELATED APPLICATIONS | MERCK SHARP & DOHME CORP. (US) | 2014-04-10 | — | — | WO | disclosed |
| EP-1701954-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066165-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2005-07-21 | — | — | WO | disclosed |
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | disclosed |
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186755-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | LOXL2, LOXL1, LOX | NOTUM 590/4885HSD17B3 1245/4885DRD2 4268/4885 |
| US-20230050653-A1 | ROCK INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF | ROCK1, CYP11B1, CYP4A11 | NOTUM 83/4885HSD17B3 165/4885DRD2 3504/4885 |
| US-20150225365-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | CYP11B1, CYP11B2, HSD11B1 | NOTUM 525/4885HSD17B3 10/4885DRD2 3365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.