Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 7/20 | 0.52 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.52 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | TACR2 | P21452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21499657 | 0.94 | TRPC5 (0.52) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL21316291 | 0.92 | TRPC5 (0.54) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL21316305 | 0.92 | TRPC5 (0.43) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19505055 | 0.91 | TRPC5 (0.56) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL21499665 | 0.91 | TRPC5 (0.51) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19505070 | 0.90 | TRPC5 (0.52) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19505475 | 0.90 | TRPC5 (0.48) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19505469 | 0.89 | TRPC5 (0.49) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL24133837 | 0.89 | TRPC5 (0.57) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL21316349 | 0.89 | TRPC5 (0.50) | TRPC5TRPC4TRPC1P2RX3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969736-B2 | Substituted xanthines and methods of use thereof | HYDRA BIOSCIENCES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | TRPC5, TRPC7, TRPC4 | TRPC5 1/4885TRPC4 3/4885TRPC1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.