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TRPC7

Short transient receptor potential channel 7 · Q9HCX4 · TRPC7 on Sugi Atlas →

1,826 patent compounds predicted against TRPC7, 881 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4717811 SCHEMBL4717811 0.51 4/20
SCHEMBL4458503 SCHEMBL4458503 0.53 3/20
SCHEMBL1720599 SCHEMBL1720599 0.52 3/20
SCHEMBL4202199 SCHEMBL4202199 0.45 3/20
SCHEMBL4241218 SCHEMBL4241218 0.44 3/20
SCHEMBL973056 SCHEMBL973056 0.38 3/20
SCHEMBL7379278 SCHEMBL7379278 0.56 2/20
SCHEMBL3707829 SCHEMBL3707829 0.54 2/20
SCHEMBL12210756 SCHEMBL12210756 0.53 2/20
SCHEMBL171313 SCHEMBL171313 0.52 2/20
SCHEMBL7374322 SCHEMBL7374322 0.52 2/20
SCHEMBL171541 SCHEMBL171541 0.52 2/20
SCHEMBL8174460 SCHEMBL8174460 0.52 2/20
SCHEMBL7411253 SCHEMBL7411253 0.52 2/20
SCHEMBL171472 SCHEMBL171472 0.51 2/20
SCHEMBL2712269 SCHEMBL2712269 0.51 2/20
SCHEMBL4470242 SCHEMBL4470242 0.51 2/20
SCHEMBL171583 SCHEMBL171583 0.50 2/20
SCHEMBL3100698 SCHEMBL3100698 0.50 2/20
SCHEMBL2523964 SCHEMBL2523964 0.49 2/20

Clinical trials — most relevant to TRPC7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Switching From Restasis to TRYPTYR PHASE4NOT_YET_RECRUITING
Investigator Initiated Trial Using Dry Eye Surveys to Evaluate and Better Understand FDA Approved Acoltremon Treatment for Dry Eye Disease in Real World Treatment Settings (DESERT) PHASE4NOT_YET_RECRUITING
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy PHASE3COMPLETED
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease PHASE2COMPLETED
TRPM8 Activators for Peripheral Neuropathy PHASE2ACTIVE_NOT_RECRUITING
Calcium Channel Blockade in Primary Aldosteronism PHASE2COMPLETED
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction PHASE2ACTIVE_NOT_RECRUITING
The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer PHASE1RECRUITING
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Peripheral KV7 Activation for Pain Relief EARLY_PHASE1COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A EARLY_PHASE1COMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
The Natural History of TRPV4 Neuropathy nanRECRUITING
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis nanUNKNOWN
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Visual Activity Evoked by Infrared in Humans After Dark Adaptation nanCOMPLETED
Affective Touch, Hedonia and Suicidal Behavior nanCOMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors nanUNKNOWN
Trigeminal Endonasal Perception: A Predictor for Septoplasty Outcome nanCOMPLETED
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TRPC7 binder may also engage these)

ProteinNameSimilarity
Q9WVC5 — 1.000 Q9WVC5 →
TRPC3 Short transient receptor potential channel 3 0.991 landscape →
Q9JMI9 — 0.983 Q9JMI9 →
Q9QZC1 — 0.982 Q9QZC1 →
TRPC6 Short transient receptor potential channel 6 0.976 landscape →
Q61143 — 0.974 Q61143 →
Q91YD4 — 0.972 Q91YD4 →
Q9MYW0 — 0.971 Q9MYW0 →
E9PTA2 — 0.968 E9PTA2 →
Q8C5H1 — 0.965 Q8C5H1 →
TRPM2 Transient receptor potential cation channel subfamily M member 2 0.962 landscape →
A6QLE6 — 0.961 A6QLE6 →
Q32M45 — 0.959 Q32M45 →
KCNT2 Potassium channel subfamily T member 2 0.953 landscape →
Q6NXT6 — 0.953 Q6NXT6 →
Q4VBD2 — 0.952 Q4VBD2 →
Q9TU72 — 0.950 Q9TU72 →
Q5ZLG8 — 0.950 Q5ZLG8 →
Q8BWB6 — 0.948 Q8BWB6 →
Q9QZ71 — 0.948 Q9QZ71 →
D3Z649 — 0.948 D3Z649 →
Q6UVM4 — 0.948 Q6UVM4 →
P13666 — 0.947 P13666 →
Q9QZ70 — 0.946 Q9QZ70 →
P20595 — 0.945 P20595 →
Q86TD4 — 0.944 Q86TD4 →
P13264 — 0.944 P13264 →
Q9UBH6 — 0.944 Q9UBH6 →
Q4R766 — 0.944 Q4R766 →
Q4ZHR9 — 0.944 Q4ZHR9 →