Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A1 | P60842 | 19/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silvestrol SCHEMBL29391620 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL19678561 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| 2'-Episilvestrol SCHEMBL29384144 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL19683897 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL24180257 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL19666161 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL24426807 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL29959484 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL5807124 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A | |
| Silvestrol SCHEMBL18862668 | 1.00 | EIF4A1 (1.00) | EIF4A1CYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170304261-A1 | SILVESTROL, SILVESTROL ANALOGS AND USES THEREOF | OHIO STATE INNOVATION FOUNDATION | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170304261-A1 | SILVESTROL, SILVESTROL ANALOGS AND USES THEREOF | CD4, HAVCR2, IFNG | EIF4A1 2206/4885CYP3A4 2559/4885HIF1A 1552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.