SCHEMBL19508771

SCHEMBL19508771

O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOCCO)c3C2=O)C(=O)N1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 5/20 0.67
CRBN Q96SW2 10/20 0.65
DDB1 Q16531 8/20 0.65
CA2 P00918 2/20 0.64
DYRK2 Q92630 1/20 0.63
IDO1 P14902 1/20 0.57
BCL2 P10415 1/20 0.56
MCL1 Q07820 1/20 0.56
TNF P01375 1/20 0.55
IL1B P01584 1/20 0.55
TBXA2R P21731 1/20 0.55
IKZF1 Q13422 1/20 0.55
IKZF3 Q9UKT9 1/20 0.55
HDAC1 Q13547 1/20 0.55
HDAC2 Q92769 1/20 0.55
EGFR P00533 1/20 0.55
ERBB2 P04626 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19453139 1.00 STAT3 (0.67) STAT3CRBNDDB1CA2DYRK2
SCHEMBL29658250 1.00 STAT3 (0.67) STAT3CRBNDDB1CA2DYRK2
SCHEMBL20305742 1.00 STAT3 (0.67) STAT3CRBNDDB1CA2DYRK2
SCHEMBL30312821 1.00 STAT3 (0.67) STAT3CRBNDDB1CA2DYRK2
SCHEMBL29658244 1.00 STAT3 (0.67) STAT3CRBNDDB1CA2DYRK2
SCHEMBL19475751 1.00 STAT3 (0.67) STAT3CRBNDDB1CA2DYRK2
SCHEMBL19475684 0.99 CRBN (0.66) STAT3CRBNDDB1CA2DYRK2
SCHEMBL29362368 0.99 CRBN (0.66) STAT3CRBNDDB1CA2DYRK2
SCHEMBL26813299 0.98 STAT3 (0.65) STAT3CRBNDDB1CA2DYRK2
SCHEMBL26813160 0.97 STAT3 (0.64) STAT3CRBNDDB1CA2DYRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260042762-A1 MERTK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-02-12 US disclosed
US-20250312462-A1 PAK1 DEGRADERS AND METHODS OF USE THEREOF INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) 2025-10-09 US disclosed
EP-3743069-B1 BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT BIOVENTURES LLC (US) 2025-08-06 EP disclosed
EP-4522158-A2 PAK1 DEGRADERS AND METHODS OF USE THEREOF Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (US) 2025-03-19 EP disclosed
US-20250073218-A1 NLRP3 PROTEIN DEGRADATION INDUCING COMPOUND UPPTHERA (KR) 2025-03-06 US disclosed
WO-2025034789-A1 ARYLBENZOISOXAZOLE COMPOUNDS AS IP6K AND IPMK DEGRADERS AND METHODS OF USE THEREOF THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2025-02-13 WO disclosed
US-12118414-B2 BCL-2 proteins degraders for cancer treatment BIOVENTURES, LLC (US) 2024-10-15 US disclosed
WO-2024108009-A1 DYRK/CLK PROTACS AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-05-23 WO disclosed
WO-2024108009-A1 DYRK/CLK PROTACS AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-05-23 WO disclosed
CN-112105360-B BCL-2 protein degrading agent for cancer treatment 生物风险投资有限责任公司 2024-01-30 CN disclosed
US-20220017510-A1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. 2022-01-20 US disclosed
US-11161842-B2 Bifunctional molecules for degradation of EGFR and methods of use DANA-FARBER CANCER INSTITUTE, INC. (US) 2021-11-02 US disclosed
EP-3445357-B1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE DANA FARBER CANCER INST INC (US) 2021-05-26 EP disclosed
CN-112105360-A BCL-2 protein degrading agents for cancer treatment 生物风险投资有限责任公司 2020-12-18 CN disclosed
EP-3743069-A1 BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT BioVentures, LLC (US) 2020-12-02 EP disclosed
US-20200102298-A1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-04-02 US disclosed
US-10450310-B2 Bifunctional molecules for degradation of EGFR and methods of use DANA-FARBER CANCER INSTITUTE, INC. (US) 2019-10-22 US disclosed
WO-2019144117-A1 BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT BIOVENTURES, LLC (US) 2019-07-25 WO disclosed
US-20190106417-A1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2019-04-11 US disclosed
WO-2017185036-A1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE DANA FARBER CANCER INSTITUTE, INC. (US) 2017-10-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190106417-A1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE EGFR, ERBB2, ERBB3 STAT3 3043/4885CRBN 157/4885DDB1 404/4885
US-20220017510-A1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE EGFR, ERBB2, ERBB3 STAT3 3043/4885CRBN 157/4885DDB1 404/4885
US-12118414-B2 BCL-2 proteins degraders for cancer treatment BCL2, BCL2L1, BCL2L2 STAT3 1387/4885CRBN 263/4885DDB1 163/4885
US-20250073218-A1 NLRP3 PROTEIN DEGRADATION INDUCING COMPOUND NLRP3, XIAP, NLRP1 STAT3 1448/4885CRBN 365/4885DDB1 304/4885
US-20200102298-A1 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE EGFR, ERBB2, ERBB3 STAT3 3043/4885CRBN 157/4885DDB1 404/4885
US-20260042762-A1 MERTK DEGRADERS AND USES THEREOF MERTK, CRKL, OSTC STAT3 4380/4885CRBN 39/4885DDB1 2712/4885
US-11161842-B2 Bifunctional molecules for degradation of EGFR and methods of use EGFR, ERBB2, ERBB3 STAT3 3043/4885CRBN 157/4885DDB1 404/4885
US-20250312462-A1 PAK1 DEGRADERS AND METHODS OF USE THEREOF PAK1, PAK2, PAK6 STAT3 3029/4885CRBN 1044/4885DDB1 938/4885
US-10450310-B2 Bifunctional molecules for degradation of EGFR and methods of use EGFR, ERBB2, ERBB3 STAT3 3043/4885CRBN 157/4885DDB1 404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.