Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 4/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951541 | 0.90 | BRD4 (0.41) | CYP4F2CYP4A11PTGER1PTGER4PTGER3 | |
| SCHEMBL13516904 | 0.83 | MGMT (0.48) | PTGER1PTGER4PTGER3PTGER2BRD4 | |
| SCHEMBL1950676 | 0.79 | SGMS2 (0.50) | BRD4IDO1 | |
| SCHEMBL1908407 | 0.79 | BRD4 (0.40) | PTGER1PTGER4PTGER3PTGER2BRD4 | |
| SCHEMBL1948178 | 0.77 | BRD4 (0.56) | PTGER1BRD4IDO1KMT2A | |
| SCHEMBL1951712 | 0.77 | SGMS2 (0.50) | PTGER1BRD4TP53MDM2KMT2A | |
| SCHEMBL1948483 | 0.75 | IDO1 (0.42) | CYP4F2CYP4A11BRD4IDO1MRGPRX4 | |
| SCHEMBL1947684 | 0.75 | SGMS2 (0.43) | PTGER1BRD4IDO1KMT2A | |
| SCHEMBL12544578 | 0.74 | BRD4 (0.40) | PTGER1PTGER4PTGER3PTGER2BRD4 | |
| SCHEMBL1950683 | 0.74 | MRGPRX4 (0.48) | CYP4F2CYP4A11BRD4MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110136796-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-06-09 | — | — | US | claimed |
| US-9174942-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174942-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174942-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140323740-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-10-30 | — | — | US | disclosed |
| US-20140323740-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-10-30 | — | — | US | disclosed |
| US-8748469-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748469-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748469-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-06-10 | — | — | US | disclosed |
| US-20110136796-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110136796-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110136796-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-06-09 | — | — | US | disclosed |
| WO-2009132238-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323740-A1 | IDO Inhibitors | IDO1, IDO2, INMT | CYP4F2 792/4885CYP4A11 1381/4885PTGER1 1451/4885 |
| US-20110136796-A1 | IDO Inhibitors | IDO1, IDO2, INMT | CYP4F2 792/4885CYP4A11 1381/4885PTGER1 1451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.