Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 11/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375776 | 0.76 | DHFR (0.42) | HRH4HRH3DHFRADORA2AHRH1 | |
| SCHEMBL22256188 | 0.73 | HTT (0.45) | HRH4DHFRADORA2APIK3CG | |
| SCHEMBL20780662 | 0.73 | CCR1 (0.45) | DHFRADORA2A | |
| SCHEMBL20145315 | 0.73 | TLR8 (0.44) | DHFRADORA2APIK3CG | |
| SCHEMBL1219738 | 0.73 | TLR8 (0.44) | DHFRADORA2APIK3CG | |
| SCHEMBL19520168 | 0.72 | KCNH2 (0.58) | PARP1KCNH2HRH4HRH3DHFR | |
| SCHEMBL1008883 | 0.70 | TLR7 (0.46) | PARP1HRH4 | |
| SCHEMBL1008149 | 0.70 | PARP1 (0.42) | PARP1KCNH2ADORA2AHRH2 | |
| SCHEMBL20145344 | 0.70 | DHFR (0.43) | KCNH2HRH4HRH3F2RDHFR | |
| SCHEMBL24506585 | 0.69 | KDM4E (0.40) | KCNH2HRH4HRH3DHFRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321265-B1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES INC (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-3097102-B1 | TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS | GILEAD SCIENCES INC (US) | 2017-10-18 | — | — | EP | disclosed |