Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 5/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17544407 | 0.86 | AGTR1 (0.44) | THRBTP53AGTR1 | |
| SCHEMBL17549942 | 0.84 | TP53 (0.39) | THRBTP53POLBMAPTAGTR1 | |
| SCHEMBL17545002 | 0.83 | THRB (0.40) | THRBTP53POLBMAPTRAB9A | |
| SCHEMBL19522734 | 0.80 | THRB (0.36) | THRBENPP2TP53POLBMAPT | |
| SCHEMBL17549892 | 0.77 | AGTR1 (0.44) | TP53AGTR1 | |
| SCHEMBL17544778 | 0.75 | TP53 (0.39) | TP53POLBMAPTRAB9AAGTR1 | |
| SCHEMBL17683843 | 0.73 | TP53 (0.40) | TP53POLBMAPTRAB9A | |
| SCHEMBL17544604 | 0.71 | PDE6D (0.42) | TP53MAPTRAB9AAGTR1 | |
| SCHEMBL17544765 | 0.70 | TP53 (0.40) | TP53POLBMAPTRAB9A | |
| SCHEMBL17670473 | 0.69 | AGTR1 (0.41) | ENPP2TP53MAPTCNR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802941-B2 | Compounds and methods for inhibiting histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-10-31 | — | — | US | disclosed |