Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90B1 | P14625 | 6/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.43 |
| ▸ | WDR5 | P61964 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17670341 | 0.86 | HSP90AA1 (0.47) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL17670484 | 0.75 | HSP90AA1 (0.44) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL17544575 | 0.75 | HSP90B1 (0.53) | HSP90B1HSP90AA1WDR5 | |
| SCHEMBL17544476 | 0.74 | HSP90AA1 (0.43) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL17549883 | 0.73 | HSP90AA1 (0.44) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL17544568 | 0.73 | HSP90AA1 (0.41) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL17670437 | 0.71 | HSP90AA1 (0.42) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL17670432 | 0.71 | HSP90AA1 (0.41) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL17544785 | 0.70 | HSP90AA1 (0.42) | HSP90B1HSP90AA1WDR5LMNATP53 | |
| SCHEMBL19522724 | 0.70 | THRB (0.36) | TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802941-B2 | Compounds and methods for inhibiting histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-10-31 | — | — | US | disclosed |