Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.69 |
| ▸ | LCK | P06239 | 8/20 | 0.69 |
| ▸ | EGFR | P00533 | 6/20 | 0.69 |
| ▸ | ITK | Q08881 | 6/20 | 0.69 |
| ▸ | JAK3 | P52333 | 4/20 | 0.69 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.59 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 3/20 | 0.51 |
| ▸ | LYN | P07948 | 3/20 | 0.51 |
| ▸ | HCK | P08631 | 3/20 | 0.51 |
| ▸ | FGR | P09769 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.51 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | YES1 | P07947 | 2/20 | 0.51 |
| ▸ | BLK | P51451 | 2/20 | 0.51 |
| ▸ | BMX | P51813 | 2/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14617791 | 0.86 | BTK (0.78) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL25069009 | 0.84 | NUDT14 (0.69) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL15517319 | 0.84 | BTK (0.81) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL17090646 | 0.83 | BTK (0.80) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL22909341 | 0.82 | NUDT14 (0.72) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14643776 | 0.82 | BTK (0.76) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14617765 | 0.82 | BTK (0.76) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL16701418 | 0.82 | BTK (0.67) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL408564 | 0.81 | BTK (1.00) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14617775 | 0.81 | BTK (0.80) | BTKLCKEGFRITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9801881-B2 | Use of inhibitors of bruton's tyrosine kinase (BTK) | PHARMACYCLICS LLC (US) | 2017-10-31 | — | — | US | disclosed |