Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of R-Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 2/20 | 1.00 |
| ▸ | CXCR2 | P25025 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL2896 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8577572 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL29396875 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL16757741 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL679920 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL66987 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL29353694 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL3843886 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8754790 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL23391019 | 0.98 | PTGS1 (0.97) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5639 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260041660-A1 | Compositions And Methods for Treating Acute Respiratory Distress Syndrome (ARDS) And Inflammatory Disorders Caused by Corona Viruses and Other Respiratory Pathogens or Agents That Mediate Pulmonary Injury, Inflammation or Acute Respiratory Distress, And Related Compositions and Methods for Treating and Preventing Human SARS Coronavirus Infection, COVID-19 Disease and Related Symptoms | CHANG RICHARD L (US) | 2026-02-12 | — | — | US | claimed |
| US-20250275573-A1 | ACOUSTOFLUIDIC DEVICE FOR GENERATING AEROSOLS | Leibniz-Institut für Festkörper- und, Werkstoffforschung Dresden e. V. (DE) | 2025-09-04 | — | — | US | claimed |
| EP-4609959-A1 | ACOUSTOFLUIDIC AEROSOL GENERATING DEVICE | Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden e.V. (DE) | 2025-09-03 | — | — | EP | claimed |
| US-12285396-B2 | Co-crystal of ketoprofen, compositions comprising the same, process of producing the same, and uses thereof | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2025-04-29 | — | — | US | claimed |
| US-20250017846-A1 | TOPICAL ANALGESICS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2025-01-16 | — | — | US | claimed |
| US-20240082202-A1 | Compositions And Methods for Treating Acute Respiratory Distress Syndrome (ARDS) And Inflammatory Disorders Caused by Corona Viruses and Other Respiratory Pathogens or Agents That Mediate Pulmonary Injury, Inflammation or Acute Respiratory Distress, And Related Compositions and Methods for Treating and Preventing Human SARS Coronavirus Infection, COVID-19 Disease and Related Symptoms | CHANG RICHARD L (US) | 2024-03-14 | — | — | US | claimed |
| EP-4304570-A2 | COMPOSITIONS AND METHODS FOR TREATING ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) AND INFLAMMATORY DISORDERS CAUSED BY CORONAVIRUSES | Phor-Med, Inc. (US) | 2024-01-17 | — | — | EP | claimed |
| CN-117015375-A | Compositions and methods for treating Acute Respiratory Distress Syndrome (ARDS) and inflammatory conditions caused by coronaviruses | 福尔医学公司 | 2023-11-07 | — | — | CN | claimed |
| EP-3676422-B1 | WEAR RESISTANT PVD TOOL COATING CONTAINING TIALN NANOLAYER FILMS | WALTER AG (DE) | 2023-10-18 | — | — | EP | claimed |
| US-20230248684-A1 | COMPOSITIONS AND METHODS FOR TREATING ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) AND INFLAMMATORY DISORDERS CAUSED BY CORONAVIRUSES AND OTHER RESPIRATORY PATHOGENS OR AGENTS THAT MEDIATE PULMONARY INJURY, INFLAMMATION OR ACUTE RESPIRATORY DISTRESS, AND RELATED COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HUMAN SARS CORONAVIRUS INFECTION, COVID-19 DISEASE AND RELATED SYMPTOMS | PHOR-MED, INC. | 2023-08-10 | — | — | US | claimed |
| EP-0599967-B1 | ARYLALKANOIC ACID RESOLUTION | MENARINI LAB (ES) | 1997-12-10 | — | — | EP | claimed |
| US-5516690-A | ANTIINFLAMMATORY | LABORABOTIOS MENARINI, S.A. (ES) | 1996-05-14 | — | — | US | claimed |
| EP-0703212-A1 | Process for optically resolving 2-(3-benzoylphenyl) propionic acid | NAGASE & COMPANY, LTD. (JP) | 1996-03-27 | — | — | EP | claimed |
| US-5426215-A | Mixing with base and ketone solvent, then controlled heating of solution | RHONE-POULENC RORER, S.A. (FR) | 1995-06-20 | — | — | US | claimed |
| US-4851426-A | PRODRUGS | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1989-07-25 | — | — | US | claimed |
| EP-0012621-B2 | ANALGESIC COMPOSITION COMPRISING ACETAMINOPHEN AS A POTENTIATING AGENT | McNeilab, Inc. (US) | 1989-03-22 | — | — | EP | claimed |
| EP-0064693-B1 | PROCESS FOR THE PRODUCTION OF 1-BENZOYLAMINO-8-HYDROXYNAPHTHALENE-4,6-DISULPHONIC ACID (BENZOYL K-ACID) | BAYER AG (DE) | 1985-04-10 | — | — | EP | claimed |
| EP-0012621-B1 | ANALGESIC COMPOSITION COMPRISING ACETAMINOPHEN AS A POTENTIATING AGENT | McNeilab, Inc. (US) | 1983-06-08 | — | — | EP | claimed |
| US-4233315-A | M-BENZOYLHYDRATROPIC ACID AND ACETAMINOPHEN | MCNEILAB, INC. (US) | 1980-11-11 | — | — | US | claimed |
| EP-0012621-A1 | Analgesic composition comprising acetaminophen as a potentiating agent | McNeilab, Inc. (US) | 1980-06-25 | — | — | EP | claimed |