Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 2/20 | 1.00 |
| ▸ | CXCR2 | P25025 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL2896 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL195303 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8577572 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL29396875 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL16757741 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL679920 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL66987 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL29353694 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8754790 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL23391019 | 0.98 | PTGS1 (0.97) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1236758-C | Slow-releasing injection contg. hydrocastor oil/medicine (for treatment) solid dispersion microparticle | WANG YUWAN (CN) | 2006-01-18 | — | — | CN | claimed |
| CN-1583174-A | Long-term injection containing ethylcellulose and fatty acid ester | WANG YUWAN (CN) | 2005-02-23 | — | — | CN | claimed |
| CN-1533764-A | Slow release injection preparation containing non sterol anti inflammation medicine | 王玉万 | 2004-10-06 | — | — | CN | claimed |
| CN-1490009-A | Sustained release injection containing medicine against coccindian | 王玉万 | 2004-04-21 | — | — | CN | claimed |
| CN-1461639-A | Slow-releasing injection contg. hydrocastor oil/medicine (for treatment) solid dispersion microparticle | WANG YUWAN (CN) | 2003-12-17 | — | — | CN | claimed |
| CN-1444925-A | Long acting injection containing ethyl cellulose for animal | WANG YUWAN (CN) | 2003-10-01 | — | — | CN | claimed |
| US-20210244742-A1 | COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF | HSU JOHN (US) | 2021-08-12 | — | — | US | disclosed |
| WO-2021110085-A1 | METHOD FOR ASSOCIATING WITH EXPRESSION LEVEL OF AKR1C3 ENZYME VIA CONTENT OF PROSTAGLANDIN, AND USE OF SCREENING FOR DRUG ADMINISTRATION | 深圳艾欣达伟医药科技有限公司 | 2021-06-10 | — | — | WO | disclosed |
| US-10653700-B2 | Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof | HSU JOHN (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180296565-A1 | COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF | HSU JOHN (US) | 2018-10-18 | — | — | US | disclosed |
| US-10004749-B2 | Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof | HSU JOHN (US) | 2018-06-26 | — | — | US | disclosed |
| US-20170020885-A1 | Composition Comprising a Therapeutic Agent and a Respiratory Stimulant and Methods for the Use Thereof | HSU JOHN (US) | 2017-01-26 | — | — | US | disclosed |
| US-20160175436-A1 | COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGY THERAPIES | VICUS THERAPEUTICS LLC (US) | 2016-06-23 | — | — | US | disclosed |
| EP-0215423-A2 | Transdermally resorbable aqueous compositions of arylpropionic-acid derivatives and process for their preparation | Dolorgiet GmbH & Co. KG (DE) | 1987-03-25 | — | — | EP | disclosed |
| EP-0201828-A2 | Components for therapeutical drug delivery devices | BAYER AG (DE) | 1986-11-20 | — | — | EP | disclosed |
| US-4623346-A | Isobutylene polymer active compound release systems | BAYER AKTIENGESELLSCHAFT (DE) | 1986-11-18 | — | — | US | disclosed |
| EP-0132690-A1 | Thermoplastics containing antiphlogistics | Troponwerke GmbH & Co. KG (DE) | 1985-02-13 | — | — | EP | disclosed |
| US-4292319-A | MIXTURE WITH AN ANTIULCER AGENT | BOEHRINGER INGELHEIM GMBH (DE) | 1981-09-29 | — | — | US | disclosed |
| US-4256747-A | ANTIINFLAMMATORY AGENTS, PYRIDO/2,3B//1,4/BENZODIAZEPIN-6-ONES | BOEHRINGER INGELHEIM GMBH (DE) | 1981-03-17 | — | — | US | disclosed |
| US-4154833-A | INDOMETHACIN (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID) WITH PIRENZEPINE (5,11-DIHYDRO-11-((4-METHYL-1-PIPERAZINYL)-ACETYL)-6H-PYRIDO(2,3 -B)(1,4)BENZODIAZEPIN-6-ONE) | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170020885-A1 | Composition Comprising a Therapeutic Agent and a Respiratory Stimulant and Methods for the Use Thereof | OPRM1, OPRL1, OPRK1 | PTGS1 552/4885PTGS2 1133/4885MAPT 3370/4885 |
| US-20210244742-A1 | COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF | OPRM1, OPRL1, OPRK1 | PTGS1 753/4885PTGS2 1125/4885MAPT 2759/4885 |
| US-20180296565-A1 | COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF | OPRM1, OPRL1, OPRK1 | PTGS1 552/4885PTGS2 1133/4885MAPT 3370/4885 |
| US-10004749-B2 | Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof | OPRM1, OPRL1, OPRK1 | PTGS1 552/4885PTGS2 1133/4885MAPT 3370/4885 |
| US-10653700-B2 | Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof | OPRM1, OPRL1, OPRK1 | PTGS1 552/4885PTGS2 1133/4885MAPT 3370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.