Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 10/20 | 0.66 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.64 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | PPARD | Q03181 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554134 | 0.87 | SERPINE1 (0.68) | SERPINE1KCNK2KCNK10AKR1C4AKR1C3 | |
| SCHEMBL19554229 | 0.84 | SERPINE1 (0.61) | SERPINE1KCNK2KCNK10AKR1C4AKR1C3 | |
| SCHEMBL418647 | 0.84 | SERPINE1 (0.66) | SERPINE1KCNK2KCNK10PPARGPPARD | |
| SCHEMBL19554148 | 0.81 | DHODH (0.70) | SERPINE1KCNK2KCNK10AKR1C4AKR1C3 | |
| SCHEMBL1308660 | 0.81 | TMPRSS4 (0.64) | SERPINE1KCNK2KCNK10PPARGPPARD | |
| SCHEMBL19554329 | 0.80 | MAPT (0.59) | KCNK2KCNK10AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL420142 | 0.80 | SERPINE1 (1.00) | SERPINE1KCNK2KCNK10PPARGNR1H4 | |
| SCHEMBL19575451 | 0.78 | KMT2A (0.76) | RAB9A | |
| SCHEMBL6349535 | 0.78 | SERPINE1 (0.74) | SERPINE1KCNK2KCNK10AKR1C4AKR1C3 | |
| SCHEMBL6358123 | 0.78 | SERPINE1 (0.89) | SERPINE1KCNK2KCNK10AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | claimed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |