Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.41 |
| ▸ | CLK1 | P49759 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299629 | 0.84 | SMN1; SMN2 (0.57) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL4649325 | 0.80 | DYRK1A (0.40) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL6299396 | 0.79 | HDAC1 (0.50) | NPC1RAB9ASMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL10314836 | 0.78 | HDAC6 (0.37) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL14943039 | 0.78 | NPC1 (0.37) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL10143895 | 0.76 | DYRK1A (0.39) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL2944163 | 0.75 | RXRA (0.50) | NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL24124671 | 0.72 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8148280 | 0.72 | HDAC6 (0.41) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL13032437 | 0.72 | HPGD (0.38) | DYRK1ADYRK1BCLK1HSD17B1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |