Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.40 |
| ▸ | CLK1 | P49759 | 6/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554202 | 0.80 | DYRK1A (0.41) | DYRK1ADYRK1BCLK1HDAC1HDAC6 | |
| SCHEMBL19029299 | 0.77 | HDAC1 (0.50) | HDAC1HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL727139 | 0.73 | CES2 (0.52) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL29375279 | 0.73 | CES2 (0.52) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL11809774 | 0.72 | CYP1A2 (0.47) | DYRK1ADYRK1BCLK1HDAC1TBXAS1 | |
| SCHEMBL1021640 | 0.72 | CTNNB1 (0.57) | DYRK1AHDAC8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9390563 | 0.71 | CES2 (0.42) | DYRK1ADYRK1BCLK1NPC1RAB9A | |
| SCHEMBL1681902 | 0.71 | CES2 (0.50) | SMN1; SMN2 | |
| SCHEMBL18003152 | 0.70 | CYP2A6 (0.39) | HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8775402 | 0.69 | LCK (0.48) | DYRK1ADYRK1BCLK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963255-A1 | SYNEPHRINE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | UNIVERSITEIT GENT (BE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007071452-A1 | SYNEPHRINE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | UNIVERSITEIT GENT (BE) | 2007-06-28 | — | — | WO | disclosed |