Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.42 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1575174 | 1.00 | GPR119 (0.50) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL21564441 | 0.88 | NR1H2 (0.43) | GPR119DPP4L3MBTL1 | |
| SCHEMBL4417481 | 0.86 | EED (0.45) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL12082901 | 0.85 | DPP4 (0.55) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL1295289 | 0.85 | GPR119 (0.56) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL13630780 | 0.84 | EPHX1 (0.50) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL13316244 | 0.83 | DPP4 (0.42) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL13600068 | 0.83 | GPR119 (0.56) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL25819386 | 0.83 | GPR119 (0.56) | GPR119HPGDDPP4RECQLEPHX1 | |
| SCHEMBL25819368 | 0.83 | GPR119 (0.56) | GPR119HPGDDPP4RECQLEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452451-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | Bristol-Myers Squibb Company (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017192813-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-11-09 | — | — | WO | disclosed |