Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25497382 | 0.93 | ALDH1A1 (0.34) | SIGMAR1KDM4EHRH3DRD3 | |
| SCHEMBL15316722 | 0.82 | CHKA (0.40) | CHKASIGMAR1HTR7CA2NCF1 | |
| SCHEMBL21941251 | 0.76 | MEN1 (0.44) | KDM4EHRH3KCNH2 | |
| SCHEMBL10192139 | 0.74 | KDM1A (0.39) | SIGMAR1KDM4E | |
| SCHEMBL4808739 | 0.73 | PSMB1 (0.44) | KDM4EHRH3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL25492954 | 0.72 | HRH3 (0.43) | CHKASIGMAR1HTR7HRH3DRD3 | |
| SCHEMBL14500230 | 0.72 | KDM4E (0.51) | CHKASIGMAR1CA2NCF1PRMT6 | |
| SCHEMBL2916819 | 0.72 | CHKA (0.43) | CHKASIGMAR1HTR7CA2NCF1 | |
| SCHEMBL10196944 | 0.72 | PSMB1 (0.41) | SIGMAR1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27250180 | 0.71 | CHKA (0.52) | CHKASIGMAR1HTR7CA2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809590-B2 | Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-11-07 | — | — | US | disclosed |