Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9609808 | 0.85 | SMN1; SMN2 (0.82) | SMN1; SMN2MAPTHPGDRAB9ANPC1 | |
| SCHEMBL23619661 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL2054672 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL17745117 | 0.79 | L3MBTL1 (0.50) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL6987048 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL7251623 | 0.79 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL29791243 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL11266548 | 0.78 | MAPT (0.56) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL13817781 | 0.78 | L3MBTL1 (0.79) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL11564781 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTHPGDL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |