Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11396210 | 0.87 | RAB9A (0.55) | MAPTSMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL13073364 | 0.85 | NPC1 (0.48) | MAPTSMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL13073565 | 0.83 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL8376615 | 0.82 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL2054672 | 0.82 | SMN1; SMN2 (0.62) | MAPTSMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL23343691 | 0.81 | KIF11 (0.62) | MAPTRAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL2056348 | 0.81 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL29791243 | 0.80 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL1951866 | 0.79 | RAB9A (0.55) | MAPTSMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL20458866 | 0.79 | ALDH1A1 (0.53) | MAPTSMN1; SMN2HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649214-B2 | Inhibitors of the notch transcriptional activation complex kinase (“NACK”) and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2023-05-16 | — | — | US | disclosed |
| US-4359584-A | Preparation of p-substituted, aromatic amines | BASF AKTIENGESELLSCHAFT (DE) | 1982-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11649214-B2 | Inhibitors of the notch transcriptional activation complex kinase (“NACK”) and methods for use of the same | NOTCH1, CHUK, CBFB | MAPT 2778/4885SMN1; SMN2 4745/4885HPGD 3644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.