Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19464746 | 0.87 | ESR1 (0.41) | ESR1THRATHRBDUTHSD11B1 | |
| SCHEMBL19464730 | 0.77 | GRIA4 (0.48) | ESR1THRATHRBDUTHSD11B1 | |
| SCHEMBL21690373 | 0.75 | DUT (0.56) | DUTGHSR | |
| SCHEMBL753731 | 0.74 | ESR1 (0.45) | ESR1THRATHRBHSD11B1ESR2 | |
| SCHEMBL26328525 | 0.70 | ESR1 (0.48) | ESR1THRATHRBESR2 | |
| SCHEMBL22751066 | 0.67 | ESR1 (0.50) | ESR1THRATHRBESR2 | |
| SCHEMBL21690688 | 0.67 | DUT (0.63) | DUTCNR2 | |
| SCHEMBL6685103 | 0.67 | ESR1 (0.74) | ESR1THRATHRBHSD11B1ESR2 | |
| SCHEMBL19454941 | 0.66 | ESR1 (0.58) | ESR1THRATHRBESR2 | |
| SCHEMBL16891301 | 0.66 | CNR2 (0.44) | DUTCA2GRIA4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809571-B2 | Deoxyuridine triphosphatase inhibitors | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2017-11-07 | — | — | US | disclosed |