Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | MPC2 | O95563 | 2/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559648 | 0.88 | PPARG (0.67) | PPARGMPC2CYP2C8CYP2C9LMNA | |
| SCHEMBL19559657 | 0.87 | PPARG (0.64) | PPARGMPC2CYP2C8CYP2C9LMNA | |
| SCHEMBL19559661 | 0.81 | PPARG (0.53) | PPARGMPC2CYP2C8CYP2C9L3MBTL1 | |
| SCHEMBL935850 | 0.81 | PPARG (0.77) | PPARGMPC2CYP2C8CYP2C9ALDH1A1 | |
| SCHEMBL8282079 | 0.80 | PPARG (0.53) | PPARGMPC2CYP2C8CYP2C9LMNA | |
| SCHEMBL24050788 | 0.77 | PPARG (0.55) | PPARGMPC2CYP2C8CYP2C9LMNA | |
| SCHEMBL19217851 | 0.77 | SMN1; SMN2 (0.52) | PPARGMPC2CYP2C8CYP2C9LMNA | |
| SCHEMBL25833061 | 0.77 | PPARG (0.55) | PPARGMPC2CYP2C8CYP2C9LMNA | |
| SCHEMBL22226858 | 0.76 | PPARG (0.53) | PPARGMPC2CYP2C8CYP2C9LMNA | |
| SCHEMBL19559801 | 0.75 | PPARG (0.46) | PPARGLMNAL3MBTL1POLBMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |