Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.64 |
| ▸ | MPC2 | O95563 | 2/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559661 | 0.89 | PPARG (0.53) | PPARGMPC2CYP2C8CYP2C9L3MBTL1 | |
| SCHEMBL19559640 | 0.87 | PPARG (0.52) | PPARGMPC2CYP2C8CYP2C9KMT2A | |
| SCHEMBL19559648 | 0.87 | PPARG (0.67) | PPARGMPC2CYP2C8CYP2C9KMT2A | |
| SCHEMBL19217851 | 0.84 | SMN1; SMN2 (0.52) | PPARGMPC2CYP2C8CYP2C9KMT2A | |
| SCHEMBL19559710 | 0.80 | NPC1 (0.47) | PPARGKMT2AMEN1NPC1MAPT | |
| SCHEMBL19559726 | 0.79 | PPARG (0.49) | PPARGMAPTKDM4EMCL1LTA4H | |
| SCHEMBL18541499 | 0.78 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9KMT2A | |
| SCHEMBL935826 | 0.78 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9KMT2A | |
| SCHEMBL19828831 | 0.78 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9KMT2A | |
| SCHEMBL8282085 | 0.77 | PPARG (0.66) | PPARGMPC2CYP2C8CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |