Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 8/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | MPC2 | O95563 | 2/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18214501 | 0.89 | LMNA (0.53) | SMN1; SMN2LMNAL3MBTL1PPARGCYP2C9 | |
| SCHEMBL19559661 | 0.84 | PPARG (0.53) | SMN1; SMN2L3MBTL1PPARGCYP2C9MPC2 | |
| SCHEMBL19559657 | 0.84 | PPARG (0.64) | SMN1; SMN2LMNAL3MBTL1PPARGCYP2C9 | |
| SCHEMBL19559648 | 0.83 | PPARG (0.67) | SMN1; SMN2LMNAL3MBTL1PPARGCYP2C9 | |
| SCHEMBL19559802 | 0.80 | PPARG (0.41) | LMNAL3MBTL1PPARGALDH1A1MAPT | |
| SCHEMBL936346 | 0.80 | PPARG (0.71) | SMN1; SMN2LMNAL3MBTL1PPARGCYP2C9 | |
| SCHEMBL8282075 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAL3MBTL1PPARGCYP2C9 | |
| SCHEMBL19559735 | 0.79 | PPARG (0.38) | PPARGALDH1A1HTTMAPTKDM4E | |
| SCHEMBL19559694 | 0.79 | PPARG (0.38) | PPARGALDH1A1HTTMAPTKDM4E | |
| SCHEMBL19559640 | 0.77 | PPARG (0.52) | SMN1; SMN2LMNAL3MBTL1PPARGCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-3202401-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Octeta Therapeutics, LLC (US) | 2017-08-09 | — | — | EP | disclosed |