Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559710 | 0.85 | NPC1 (0.47) | PPARGMAOBFFAR1KDM4EMAPT | |
| SCHEMBL19559802 | 0.85 | PPARG (0.41) | PPARGFFAR1CYP3A4RXRAKDM4E | |
| SCHEMBL19559724 | 0.82 | GLA (0.42) | PPARGMAOBFFAR1MCL1SIRT2 | |
| SCHEMBL19559801 | 0.81 | PPARG (0.46) | PPARGMAOBCYP3A4RXRAMAPT | |
| SCHEMBL19559762 | 0.80 | PPARG (0.45) | PPARGKCNH2FFAR1CYP3A4RXRA | |
| SCHEMBL6931578 | 0.79 | FFAR1 (0.59) | PPARGFFAR1CYP3A4RXRAMAPT | |
| SCHEMBL19217777 | 0.78 | PPARG (0.40) | PPARGFFAR1MCL1KDM4EMAPT | |
| SCHEMBL19559666 | 0.77 | PPARG (0.46) | PPARGMAOBFFAR1MAPT | |
| SCHEMBL18323953 | 0.74 | PPARG (0.66) | PPARGCYP3A4RXRAHRH3 | |
| SCHEMBL19559657 | 0.73 | PPARG (0.64) | PPARGMCL1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |