Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559801 | 0.90 | PPARG (0.46) | PPARGMAPTMAOBKDM4CMAOA | |
| SCHEMBL19559762 | 0.89 | PPARG (0.45) | FFAR1PPARGKDM4C | |
| SCHEMBL19559724 | 0.87 | GLA (0.42) | FFAR1PPARGLTA4HMAOB | |
| SCHEMBL19559666 | 0.86 | PPARG (0.46) | FFAR1PPARGMAPTLTA4HMAOB | |
| SCHEMBL19559652 | 0.85 | PPARG (0.40) | FFAR1PPARGKDM4EMAPTMAOB | |
| SCHEMBL19559802 | 0.83 | PPARG (0.41) | FFAR1PPARGKDM4EMAPTHPGD | |
| SCHEMBL19559657 | 0.80 | PPARG (0.64) | NPC1RAB9APPARGKDM4EMAPT | |
| SCHEMBL19559726 | 0.79 | PPARG (0.49) | FFAR1PPARGKDM4EMAPTLTA4H | |
| SCHEMBL18323953 | 0.79 | PPARG (0.66) | PPARGHPGDMEN1KMT2AKDM4C | |
| SCHEMBL19559692 | 0.78 | FFAR1 (0.41) | FFAR1PPARGKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |