Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | BCL2 | P10415 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523660 | 0.88 | PTGS2 (0.44) | BCL2L1PTGS2PTGS1BCL2ACHE | |
| SCHEMBL22560741 | 0.83 | PTGS2 (0.45) | BCL2L1PTGS2PTGS1BCL2ACHE | |
| SCHEMBL1959392 | 0.83 | PTGS2 (0.45) | BCL2L1PTGS2PTGS1BCL2ACHE | |
| SCHEMBL19203931 | 0.82 | PTGS2 (0.44) | BCL2L1PTGS2PTGS1BCL2ACHE | |
| SCHEMBL21851539 | 0.82 | PTGS2 (0.44) | BCL2L1PTGS2PTGS1BCL2ACHE | |
| SCHEMBL23298661 | 0.82 | PTGS2 (0.44) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL19183275 | 0.82 | PTGS2 (0.44) | BCL2L1PTGS2PTGS1BCL2ACHE | |
| SCHEMBL28437858 | 0.80 | BCL2L1 (0.48) | BCL2L1PTGS2PTGS1BCL2ALDH1A1 | |
| SCHEMBL1113744 | 0.79 | BCL2L1 (0.52) | BCL2L1PTGS2PTGS1BCL2ACHE | |
| SCHEMBL1958916 | 0.78 | PTGS2 (0.44) | BCL2L1PTGS2PTGS1BCL2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507229-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068561-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |