Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959392 | 0.86 | PTGS2 (0.45) | PTGS2PTGS1BCL2L1BCL2PKM | |
| SCHEMBL22560741 | 0.86 | PTGS2 (0.45) | PTGS2PTGS1BCL2L1BCL2PKM | |
| SCHEMBL19183275 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1BCL2L1BCL2SLC6A3 | |
| SCHEMBL21851539 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1BCL2L1BCL2SLC6A3 | |
| SCHEMBL523660 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1BCL2L1BCL2SIRT2 | |
| SCHEMBL23298661 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1BCL2L1BCL2SIRT2 | |
| SCHEMBL1956374 | 0.82 | BCL2L1 (0.42) | PTGS2PTGS1BCL2L1BCL2SLC6A3 | |
| SCHEMBL1958916 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1BCL2L1BCL2SLC6A3 | |
| SCHEMBL24917425 | 0.80 | PTGS1 (0.39) | PTGS2PTGS1BCL2L1BCL2 | |
| SCHEMBL20082221 | 0.80 | PTGS2 (0.40) | PTGS2PTGS1BCL2L1BCL2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132474-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2017-08-03 | — | — | WO | disclosed |