Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ATF4 | P18848 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555965 | 0.83 | ATF4 (0.69) | NPC1RAB9AATF4HPGDMAPT | |
| SCHEMBL25781240 | 0.82 | NPC1 (0.42) | NPC1RAB9AATF4HPGDMAPT | |
| SCHEMBL19555914 | 0.72 | ATF4 (0.52) | ATF4HPGDMAPTKDM4EHTT | |
| SCHEMBL25804554 | 0.72 | ATF4 (0.46) | NPC1RAB9AATF4HPGDMAPT | |
| SCHEMBL22956631 | 0.72 | ATF4 (0.42) | ATF4 | |
| SCHEMBL19556349 | 0.71 | ATF4 (0.63) | NPC1RAB9AATF4KDM4EKMT2A | |
| SCHEMBL19555766 | 0.71 | ATF4 (0.66) | NPC1RAB9AATF4MAPTKDM4E | |
| SCHEMBL19556252 | 0.70 | ATF4 (0.61) | NPC1RAB9AATF4SMN1; SMN2 | |
| SCHEMBL24322775 | 0.69 | NPC1 (0.53) | NPC1HPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL23149119 | 0.69 | ATF4 (0.76) | NPC1RAB9AATF4CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193063-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |