Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577397 | 0.81 | ATF4 (0.62) | NPC1ALDH1A1NPY1RNPY2RDRD2 | |
| SCHEMBL19555682 | 0.75 | ATF4 (0.70) | NPC1KMT2AATMMEN1 | |
| SCHEMBL24324540 | 0.73 | NPC1 (0.58) | NPC1ALDH1A1NPY1RNPY2RDRD2 | |
| SCHEMBL19577396 | 0.73 | PPARD (0.56) | NPC1ALDH1A1NPY1RNPY2RKMT2A | |
| SCHEMBL19577394 | 0.71 | ATF4 (0.57) | NPC1ALDH1A1POLBMAPK1 | |
| SCHEMBL19577395 | 0.71 | ATF4 (0.62) | ALDH1A1DRD2DRD4DRD3KMT2A | |
| SCHEMBL19568247 | 0.69 | NPC1 (0.46) | NPC1ALDH1A1KMT2AATMMEN1 | |
| SCHEMBL24323517 | 0.69 | PPARD (0.59) | NPC1DRD2DRD4DRD3KMT2A | |
| SCHEMBL24324518 | 0.69 | ATF4 (0.40) | — | |
| SCHEMBL24322875 | 0.69 | LMNA (0.49) | NPC1ALDH1A1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |