Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31363066 | 0.89 | GLRA1 (0.49) | TSHRL3MBTL1GLRA1ALDH1A1CYP3A4 | |
| SCHEMBL1148717 | 0.87 | GLRA1 (0.49) | GLRA1ALDH1A1HTTHDAC8SMPD1 | |
| SCHEMBL1018517 | 0.84 | GLRA1 (0.44) | GLRA1ALDH1A1HTTHDAC8SMPD1 | |
| SCHEMBL383740 | 0.82 | FOLH1 (0.55) | L3MBTL1GLRA1ALDH1A1RXRAPOLB | |
| SCHEMBL1019564 | 0.82 | HPGD (0.49) | GLRA1ALDH1A1HTTHDAC8SMPD1 | |
| SCHEMBL383729 | 0.81 | MAOB (0.55) | TSHRL3MBTL1GLRA1CYP3A4TDP1 | |
| SCHEMBL382283 | 0.80 | GLRA1 (0.60) | L3MBTL1GLRA1TDP1RXRAMAPT | |
| SCHEMBL30779582 | 0.79 | SGMS2 (0.62) | ALDH1A1PKMMAPT | |
| SCHEMBL30779557 | 0.79 | SGMS2 (0.62) | L3MBTL1GLRA1ALDH1A1MAPK1HTT | |
| SCHEMBL21644540 | 0.79 | SGMS2 (0.62) | L3MBTL1GLRA1ALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170320837-A1 | METHOD FOR TREATING INFLAMMATORY DISORDERS | SYNTA PHARMACEUTICALS CORP. | 2017-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320837-A1 | METHOD FOR TREATING INFLAMMATORY DISORDERS | TNF, IL2, IL5 | TSHR 3754/4885L3MBTL1 4488/4885GLRA1 4211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.