Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 13/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555442 | 0.89 | ATF4 (0.55) | ATF4MRGPRX4HTT | |
| SCHEMBL30026324 | 0.89 | ATF4 (0.55) | ATF4MRGPRX4HTT | |
| SCHEMBL30024684 | 0.83 | ATF4 (0.51) | ATF4MRGPRX4HTT | |
| SCHEMBL19555423 | 0.83 | ATF4 (0.51) | ATF4MRGPRX4HTT | |
| SCHEMBL30075981 | 0.82 | ATF4 (0.49) | ATF4HTT | |
| SCHEMBL19569585 | 0.81 | ATF4 (0.61) | ATF4HTTMAOB | |
| SCHEMBL30025703 | 0.79 | ATF4 (0.50) | ATF4MRGPRX4 | |
| SCHEMBL19569278 | 0.79 | ATF4 (0.53) | ATF4MRGPRX4HTT | |
| SCHEMBL19569469 | 0.79 | ATF4 (0.50) | ATF4MRGPRX4 | |
| SCHEMBL19555449 | 0.79 | ATF4 (0.53) | ATF4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |