Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 15/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555442 | 1.00 | ATF4 (0.55) | ATF4HTTMRGPRX4ADAMTS5 | |
| SCHEMBL19555423 | 0.92 | ATF4 (0.51) | ATF4HTTMRGPRX4 | |
| SCHEMBL30024684 | 0.92 | ATF4 (0.51) | ATF4HTTMRGPRX4 | |
| SCHEMBL19569585 | 0.91 | ATF4 (0.61) | ATF4HTT | |
| SCHEMBL30026187 | 0.90 | ATF4 (0.53) | ATF4HTT | |
| SCHEMBL19555449 | 0.90 | ATF4 (0.53) | ATF4HTT | |
| SCHEMBL19569278 | 0.90 | ATF4 (0.53) | ATF4HTTMRGPRX4ADAMTS5 | |
| SCHEMBL19569469 | 0.90 | ATF4 (0.50) | ATF4MRGPRX4 | |
| SCHEMBL30025703 | 0.90 | ATF4 (0.50) | ATF4MRGPRX4 | |
| SCHEMBL19569472 | 0.89 | ATF4 (0.43) | ATF4HTTMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |