Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19676362 | 0.86 | ALDH1A1 (0.53) | ALDH1A1LMNATLR2LPAR3ENPP2 | |
| SCHEMBL15636559 | 0.82 | KDM5B (0.66) | ALDH1A1LMNAKDM5BTLR2KDM5A | |
| SCHEMBL19676405 | 0.81 | KDM5B (0.47) | ALDH1A1LMNAKDM5BTLR2LPAR3 | |
| SCHEMBL19676437 | 0.80 | KDM5B (0.61) | ALDH1A1LMNAKDM5BTLR2KDM5A | |
| SCHEMBL15636393 | 0.77 | KDM5B (0.67) | ALDH1A1LMNAKDM5BTLR2KDM5A | |
| SCHEMBL16925985 | 0.77 | KDM5B (0.61) | ALDH1A1LMNAKDM5BTLR2KDM5A | |
| SCHEMBL18708527 | 0.77 | KDM5B (0.58) | ALDH1A1LMNAKDM5BTLR2KDM5A | |
| SCHEMBL16291763 | 0.76 | KDM5B (0.47) | ALDH1A1LMNAKDM5BTLR2LPAR3 | |
| SCHEMBL19676377 | 0.75 | KDM5B (0.63) | ALDH1A1LMNAKDM5BTLR2KDM5A | |
| SCHEMBL449242 | 0.72 | ALDH1A1 (0.64) | ALDH1A1LMNATLR2LPAR3ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221139-B2 | Inhibitors of histone demethylases | GILEAD SCIENCES, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20170320827-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2017-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320827-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EHMT1, KDM1B, EHMT2 | ALDH1A1 744/4885LMNA 2406/4885KDM5B 34/4885 |
| US-10221139-B2 | Inhibitors of histone demethylases | EHMT1, KDM1B, EHMT2 | ALDH1A1 744/4885LMNA 2406/4885KDM5B 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.