Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 12/20 | 0.47 |
| ▸ | KDM5A | P29375 | 7/20 | 0.47 |
| ▸ | KDM5C | P41229 | 7/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636559 | 0.86 | KDM5B (0.66) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL16291763 | 0.82 | KDM5B (0.47) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL19676437 | 0.82 | KDM5B (0.61) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL16925985 | 0.82 | KDM5B (0.61) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL18708527 | 0.82 | KDM5B (0.58) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL15636393 | 0.81 | KDM5B (0.67) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL19574690 | 0.81 | ALDH1A1 (0.46) | KDM5BKDM5AKDM5CKDM4CTLR2 | |
| SCHEMBL19565446 | 0.80 | KDM5B (0.64) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL16291627 | 0.79 | KDM5B (0.45) | KDM5BKDM5AKDM5CKDM4CKDM4A | |
| SCHEMBL19676377 | 0.79 | KDM5B (0.63) | KDM5BKDM5AKDM5CKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |