Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323140 | 1.00 | ATF4 (0.46) | ATF4LMNATP53GAAALDH1A1 | |
| SCHEMBL24322956 | 0.92 | GAA (0.47) | ATF4LMNAGAAALDH1A1MEN1 | |
| SCHEMBL19577482 | 0.92 | GAA (0.47) | ATF4LMNAGAAALDH1A1MEN1 | |
| SCHEMBL24323450 | 0.92 | GAA (0.47) | ATF4LMNAGAAALDH1A1MEN1 | |
| SCHEMBL24322967 | 0.92 | ATF4 (0.48) | ATF4LMNAGAAALDH1A1MEN1 | |
| SCHEMBL24322873 | 0.92 | ATF4 (0.48) | ATF4ALDH1A1 | |
| SCHEMBL24324506 | 0.92 | ATF4 (0.48) | ATF4LMNAGAAALDH1A1MEN1 | |
| SCHEMBL24322885 | 0.92 | ATF4 (0.49) | ATF4 | |
| SCHEMBL24324216 | 0.92 | ATF4 (0.49) | ATF4 | |
| SCHEMBL24322901 | 0.90 | ATF4 (0.45) | ATF4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193041-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |