Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 10/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324506 | 1.00 | ATF4 (0.48) | ATF4LMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL24322873 | 0.94 | ATF4 (0.48) | ATF4ALDH1A1 | |
| SCHEMBL24324216 | 0.94 | ATF4 (0.49) | ATF4 | |
| SCHEMBL24322885 | 0.94 | ATF4 (0.49) | ATF4 | |
| SCHEMBL24323450 | 0.93 | GAA (0.47) | ATF4LMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL19577482 | 0.93 | GAA (0.47) | ATF4LMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL24322956 | 0.93 | GAA (0.47) | ATF4LMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL24323140 | 0.92 | ATF4 (0.46) | ATF4LMNAGAAALDH1A1MEN1 | |
| SCHEMBL19577445 | 0.92 | ATF4 (0.46) | ATF4LMNAGAAALDH1A1MEN1 | |
| SCHEMBL24322820 | 0.92 | ATF4 (0.47) | ATF4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |