SCHEMBL19579293

SCHEMBL19579293

Cc1ccc(-c2c(-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccccc5)ccc43)ccc(-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccccc5)ccc43)c2-c2ccc(C)c(C#N)c2)cc1C#N

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
KDM4E B2RXH2 2/20 0.38
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38
MCL1 Q07820 2/20 0.36
TSHR P16473 1/20 0.36
EGLN1 Q9GZT9 1/20 0.35
MAOA P21397 1/20 0.35
HPGD P15428 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
LMNA P02545 1/20 0.35
MAPK1 P28482 1/20 0.35
NPSR1 Q6W5P4 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
HIF1A Q16665 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19697280 0.82 ALDH1A1 (0.36) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL19697267 0.81 ALDH1A1 (0.37) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL19697259 0.81 NPSR1 (0.37) ALDH1A1KDM4EGLAGAATSHR
SCHEMBL22140539 0.81 MAOA (0.41) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL23348269 0.80 ALDH1A1 (0.39) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL28571070 0.80 MCL1 (0.38) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL2138267 0.80 TSHR (0.54) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL21116902 0.79 CYP11B1 (0.42) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL21333916 0.79 SMN1; SMN2 (0.42) ALDH1A1KDM4EGLAGAAMCL1
SCHEMBL25512969 0.79 CYP11B1 (0.39) ALDH1A1KDM4EGLAGAAMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3452471-B1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-12-08 EP disclosed
WO-2017190885-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2017-11-09 WO disclosed