Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19580034 | 0.96 | SLC34A2 (0.59) | SLC34A2BRAFRAF1KDM1AHDAC1 | |
| SCHEMBL45535 | 0.94 | SLC34A2 (0.64) | SLC34A2BRAFRAF1ROCK2KDM4E | |
| SCHEMBL5999719 | 0.93 | SLC34A2 (0.65) | SLC34A2BRAFRAF1ROCK2KDM4E | |
| SCHEMBL19579976 | 0.90 | SLC34A2 (0.63) | SLC34A2BRAFRAF1ROCK2KDM4E | |
| SCHEMBL19579991 | 0.89 | SLC34A2 (0.54) | SLC34A2BRAFRAF1KDM1AHDAC1 | |
| SCHEMBL19579947 | 0.89 | SLC34A2 (0.53) | SLC34A2KDM1AHDAC1ROCK2F10 | |
| SCHEMBL19580004 | 0.89 | SLC34A2 (0.52) | SLC34A2KDM1AHDAC1ROCK2 | |
| SCHEMBL19579982 | 0.89 | SLC34A2 (0.53) | SLC34A2BRAFRAF1KDM1AHDAC1 | |
| SCHEMBL19579996 | 0.89 | SLC34A2 (0.56) | SLC34A2NAMPTBRAFRAF1ROCK2 | |
| SCHEMBL46554 | 0.88 | SLC34A2 (0.59) | SLC34A2BRAFRAF1ROCK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | claimed |