SCHEMBL19583152

SCHEMBL19583152

OC[C@H]1OC(n2cnc3c(NCc4ccccc4I)ncnc32)C[C@@H]1O

nearest known ligand 0.64

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC29A1 Q99808 1/20 0.64
PAX8 Q06710 1/20 0.57
ADORA3 P0DMS8 1/20 0.56
ADORA2A P29274 1/20 0.56
ADORA1 P30542 1/20 0.56
TSHR P16473 1/20 0.56
NFKB1 P19838 1/20 0.56
STAT6 P42226 1/20 0.56
GMNN O75496 1/20 0.56
BLM P54132 1/20 0.56
PMP22 Q01453 1/20 0.56
HIF1A Q16665 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14713455 0.90 PAX8 (0.71) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL20626481 0.90 PAX8 (0.71) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL21874990 0.90 PAX8 (0.71) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL20626480 0.90 PAX8 (0.71) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL21874994 0.89 SLC29A1 (0.64) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL19583035 0.89 SLC29A1 (0.64) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL19583009 0.89 SLC29A1 (0.64) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL19583092 0.89 SLC29A1 (0.64) SLC29A1PAX8ADORA3ADORA2AADORA1
SCHEMBL23982158 0.87 SLC29A1 (0.76) SLC29A1ADORA3ADORA1HIF1A
SCHEMBL2288114 0.87 SLC29A1 (0.76) SLC29A1ADORA3ADORA1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3229771-B1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIV PALACKEHO (CZ) 2024-04-03 EP claimed
EP-3229772-B1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIV PALACKEHO (CZ) 2020-04-29 EP claimed
US-10550144-B2 6-aryl-9-glycosylpurines and use thereof UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2020-02-04 US claimed
US-10100077-B2 6-aryl-9-glycosylpurines and use thereof UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2018-10-16 US claimed
US-20170334943-A1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2017-11-23 US claimed
US-20170326168-A1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2017-11-16 US claimed
EP-3229771-B1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIV PALACKEHO (CZ) 2024-04-03 EP disclosed
EP-3229772-B1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIV PALACKEHO (CZ) 2020-04-29 EP disclosed
US-10550144-B2 6-aryl-9-glycosylpurines and use thereof UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2020-02-04 US disclosed
US-10100077-B2 6-aryl-9-glycosylpurines and use thereof UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2018-10-16 US disclosed
US-20170334943-A1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2017-11-23 US disclosed
US-20170326168-A1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2017-11-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170326168-A1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF GART, DAO, GLA SLC29A1 125/4885PAX8 4070/4885ADORA3 553/4885
US-10550144-B2 6-aryl-9-glycosylpurines and use thereof GART, DAO, GLA SLC29A1 125/4885PAX8 4070/4885ADORA3 553/4885
US-20170334943-A1 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF UNG, FUT6, GART SLC29A1 59/4885PAX8 3745/4885ADORA3 387/4885
US-10100077-B2 6-aryl-9-glycosylpurines and use thereof UNG, FUT6, GART SLC29A1 59/4885PAX8 3745/4885ADORA3 387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.