Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.41 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.36 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19585707 | 0.85 | CRBN (0.49) | CRBNDDB1CSNK1A1IKZF1CA2 | |
| SCHEMBL19585639 | 0.77 | CRBN (0.51) | CRBNDDB1IKZF3CYP1A2TSHR | |
| SCHEMBL23589797 | 0.76 | CRBN (0.41) | CRBNDDB1CSNK1A1IKZF1IKZF3 | |
| Trifluoroacetic Acid SCHEMBL29922103 | 0.74 | CRBN (0.64) | CRBNDDB1CA2IKZF3HDAC1 | |
| Trifluoroacetic Acid SCHEMBL17839978 | 0.74 | CRBN (0.64) | CRBNDDB1CA2IKZF3HDAC1 | |
| SCHEMBL19586331 | 0.72 | ALOX15 (0.44) | CRBNDDB1IKZF3CYP1A2TSHR | |
| SCHEMBL19585379 | 0.70 | CRBN (0.42) | CRBNDDB1IKZF3CYP1A2TSHR | |
| Trifluoroacetic Acid SCHEMBL23705500 | 0.69 | CRBN (0.65) | CRBNDDB1IKZF3 | |
| Trifluoroacetic Acid SCHEMBL17873751 | 0.67 | CRBN (0.66) | CRBNDDB1IKZF1CA2IKZF3 | |
| Trifluoroacetic Acid SCHEMBL17839625 | 0.67 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197056-A1 | BROMODOMAIN TARGETING DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |