SCHEMBL19586735

SCHEMBL19586735

O=C(O)N[C@H](CO)C[C@@H]1CCCNC1=O

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.35
▸ CTSL P07711 1/20 0.33
▸ CTSB P07858 1/20 0.33
▸ HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21772494 1.00 L3MBTL1 (0.35) L3MBTL1CTSLCTSBHTT
SCHEMBL21772496 1.00 L3MBTL1 (0.35) L3MBTL1CTSLCTSBHTT
SCHEMBL6064485 0.93 CTSL (0.36) CTSLCTSB
SCHEMBL19924782 0.93 CTSL (0.36) CTSLCTSB
SCHEMBL7417089 0.93 CTSL (0.36) CTSLCTSB
SCHEMBL22750552 0.85 CAPN1 (0.45) CTSL
SCHEMBL22750553 0.85 CAPN1 (0.45) CTSL
SCHEMBL22750551 0.85 CAPN1 (0.45) CTSL
SCHEMBL30914037 0.81 CTSL (0.37) CTSLCTSB
SCHEMBL30396756 0.81 CTSL (0.37) CTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11859014-B2 Peptidomimetics for the treatment of Norovirus infection EMORY UNIVERSITY (US) 2024-01-02 — — US disclosed
WO-2022265577-A2 CORONAVIRUS ENZYME MODULATORS, METHODS OF SYNTHESIS AND USES THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2022-12-22 — — WO disclosed
US-11207370-B2 Peptidomimetics for the treatment of coronavirus and picornavirus infections EMORY UNIVERSITY (US) 2021-12-28 — — US disclosed
US-20210395300-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION UNIV EMORY (US) 2021-12-23 — — US disclosed
US-11021513-B2 Peptidomimetics for the treatment of norovirus infection EMORY UNIVERSITY (US) 2021-06-01 — — US disclosed
US-20210008150-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS EMORY UNIVERSITY 2021-01-14 — — US disclosed
WO-2020247665-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS EMORY UNIVERSITY (US) 2020-12-10 — — WO disclosed
US-20200071354-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION EMORY UNIVERSITY (US) 2020-03-05 — — US disclosed
EP-3455205-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION Emory University (US) 2019-03-20 — — EP disclosed
WO-2017197377-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION EMORY UNIVERSITY (US) 2017-11-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11021513-B2 Peptidomimetics for the treatment of norovirus infection VIP, HAVCR2, NGLY1 L3MBTL1 355/4885CTSL 280/4885CTSB 583/4885
US-11859014-B2 Peptidomimetics for the treatment of Norovirus infection VIP, HAVCR2, NGLY1 L3MBTL1 355/4885CTSL 280/4885CTSB 583/4885
US-20210008150-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS ACE2, SARS1, VIP L3MBTL1 600/4885CTSL 88/4885CTSB 764/4885
US-20200071354-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION VIP, HAVCR2, NGLY1 L3MBTL1 355/4885CTSL 280/4885CTSB 583/4885
US-11207370-B2 Peptidomimetics for the treatment of coronavirus and picornavirus infections ACE2, SARS1, VIP L3MBTL1 600/4885CTSL 88/4885CTSB 764/4885
US-20210395300-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION VIP, HAVCR2, NGLY1 L3MBTL1 355/4885CTSL 280/4885CTSB 583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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