Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TLR2 | O60603 | 13/20 | 0.49 |
| ▸ | TLR1 | Q15399 | 12/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL16714405 | 0.93 | SMN1; SMN2 (0.47) | SMN1; SMN2NPSR1TLR2TLR1P2RX7 | |
| Trifluoroacetic Acid SCHEMBL16714355 | 0.79 | CFD (0.38) | SMN1; SMN2NPSR1TLR2TLR1P2RX7 | |
| SCHEMBL6153775 | 0.77 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1TLR2TLR1CNR1 | |
| SCHEMBL3457343 | 0.77 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1TLR2TLR1CNR1 | |
| SCHEMBL6154005 | 0.77 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1TLR2TLR1CNR1 | |
| SCHEMBL7980208 | 0.77 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1TLR2TLR1CNR1 | |
| Rolicyprine SCHEMBL30616025 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2NPSR1TLR2TLR1P2RX7 | |
| Rolicyprine SCHEMBL49385 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2NPSR1TLR2TLR1P2RX7 | |
| SCHEMBL25022000 | 0.74 | TLR2 (0.60) | SMN1; SMN2NPSR1TLR2TLR1KDM1A | |
| SCHEMBL22622428 | 0.74 | TLR2 (0.60) | SMN1; SMN2NPSR1TLR2TLR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815819-B2 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2017-11-14 | — | — | US | disclosed |