Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625631 | 0.80 | PNMT (0.47) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL13930330 | 0.80 | PNMT (0.50) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL11084369 | 0.80 | PNMT (0.50) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL19592354 | 0.79 | GPR139 (0.38) | SLC6A2 | |
| SCHEMBL21975098 | 0.78 | CYP11B1 (0.35) | L3MBTL1 | |
| SCHEMBL12251272 | 0.78 | PNMT (0.45) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL20963104 | 0.78 | PNMT (0.45) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL24767350 | 0.77 | GLA (0.38) | SLC6A2SLC6A4 | |
| SCHEMBL22930915 | 0.77 | PNMT (0.47) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL19592381 | 0.77 | PNP (0.37) | PNMTACP3SLC6A2SLC6A4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9814722-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-11-14 | — | — | US | disclosed |