Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23499941 | 0.80 | AMY1A (0.44) | ALDH1A1EGFRERBB2MAPT | |
| SCHEMBL16013981 | 0.80 | EGFR (0.36) | ALDH1A1EGFRERBB2SRCGAA | |
| SCHEMBL29625666 | 0.80 | AMY1A (0.44) | ALDH1A1EGFRERBB2MAPT | |
| SCHEMBL23515197 | 0.80 | AMY1A (0.44) | ALDH1A1EGFRERBB2MAPT | |
| SCHEMBL16013200 | 0.80 | EGFR (0.36) | ALDH1A1EGFRERBB2SRCGAA | |
| SCHEMBL21883711 | 0.78 | ACHE (0.40) | ALDH1A1EGFRERBB2SRCMAPT | |
| SCHEMBL19880486 | 0.78 | NPSR1 (0.49) | ALDH1A1EGFRERBB2SRCGAA | |
| SCHEMBL28863115 | 0.78 | SRC (0.44) | ALDH1A1SRCGAAMAPTMEN1 | |
| SCHEMBL19880559 | 0.74 | TSHR (0.46) | ALDH1A1SRCGAAMAPTMEN1 | |
| SCHEMBL2927453 | 0.73 | GAA (0.32) | EGFRERBB2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964642-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2017-11-15 | — | — | EP | disclosed |