Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18659614 | 0.87 | PIK3CA (0.41) | PIK3CAPIK3CBPIK3CGPIK3CDMAP3K14 | |
| SCHEMBL1485126 | 0.80 | PIK3CA (0.41) | PIK3CAPIK3CBPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL19594444 | 0.76 | PIK3CA (0.42) | PIK3CAPIK3CDMAP3K14PIK3R1 | |
| SCHEMBL1485522 | 0.72 | ALPL (0.39) | PIK3CAPIK3CBPIK3CGPIK3CDPSEN1 | |
| SCHEMBL19594751 | 0.71 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGPIK3CDMAP3K14 | |
| SCHEMBL20862377 | 0.69 | SMN1; SMN2 (0.41) | PIK3CAPIK3CBPIK3CGPIK3CDCYP2D6 | |
| SCHEMBL19594449 | 0.68 | CYP2C9 (0.47) | PIK3CAPIK3CBPIK3CGPIK3CDMAP3K14 | |
| SCHEMBL1485001 | 0.68 | MAP3K14 (0.54) | PIK3CDMAP3K14PIK3R1 | |
| SCHEMBL1485327 | 0.67 | PIK3CA (0.70) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL12539295 | 0.66 | PIK3CD (0.66) | PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688891-B1 | BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2017-11-15 | — | — | EP | disclosed |