Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 9/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416495 | 0.80 | P4HTM (0.54) | P4HTMALDH1A1KDM4E | |
| SCHEMBL17729266 | 0.79 | P4HTM (0.47) | P4HTMHDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL31661380 | 0.77 | ALDH1A1 (0.44) | P4HTMMEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL4314837 | 0.75 | NPC1 (0.41) | P4HTMHDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL15079228 | 0.75 | SMN1; SMN2 (0.45) | P4HTMMEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL30564676 | 0.75 | SMN1; SMN2 (0.45) | P4HTMMEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL16600880 | 0.75 | GRIN2B (0.47) | P4HTMMEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL1849723 | 0.74 | PTPN1 (0.52) | P4HTMALDH1A1PTPN1KDM4E | |
| SCHEMBL13547566 | 0.74 | GSK3B (0.53) | MEN1KMT2AALDH1A1PTPN1LMNA | |
| Bromide SCHEMBL3578187 | 0.73 | PTPN1 (0.50) | P4HTMALDH1A1PTPN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794597-B1 | PYRIDINONE AND PYRIMIDINONE DERIVATIVES AS FACTOR XIA INHIBITORS | ONO PHARMACEUTICAL CO (JP) | 2017-11-15 | — | — | EP | disclosed |