Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22854273 | 0.82 | NPC1 (0.45) | NPC1ALDH1A1RAB9AGAASMN1; SMN2 | |
| SCHEMBL21416495 | 0.81 | P4HTM (0.54) | ALDH1A1P4HTMKDM4E | |
| SCHEMBL23315522 | 0.78 | ALOX15 (0.48) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL22227949 | 0.78 | P4HTM (0.55) | NPC1ALDH1A1RAB9AGAASMN1; SMN2 | |
| SCHEMBL20416193 | 0.76 | TGM2 (0.50) | NPC1ALDH1A1RAB9AGAASMN1; SMN2 | |
| SCHEMBL10123152 | 0.76 | PARP1 (0.42) | NPC1ALDH1A1RAB9ASMN1; SMN2KDR | |
| SCHEMBL19595392 | 0.75 | P4HTM (0.36) | ALDH1A1P4HTMHDAC3HDAC4HDAC1 | |
| SCHEMBL428478 | 0.75 | NPC1 (0.49) | NPC1ALDH1A1RAB9AGAASMN1; SMN2 | |
| SCHEMBL19443526 | 0.73 | PARP1 (0.46) | ALDH1A1P4HTMMAPTPIP5K1CPIK3CA | |
| SCHEMBL30871624 | 0.73 | HDAC3 (0.41) | NPC1ALDH1A1RAB9AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009154769-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY, INC. (US) | 2009-12-23 | — | — | WO | disclosed |