Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.52 |
| ▸ | DRD3 | P35462 | 9/20 | 0.52 |
| ▸ | HTR6 | P50406 | 7/20 | 0.52 |
| ▸ | HTR2A | P28223 | 6/20 | 0.52 |
| ▸ | HTR2C | P28335 | 6/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | MLNR | O43193 | 6/20 | 0.47 |
| ▸ | MOGAT2 | Q3SYC2 | 3/20 | 0.46 |
| ▸ | GHSR | Q92847 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960721 | 0.94 | DRD2 (0.51) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1959733 | 0.90 | DRD2 (0.52) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1960382 | 0.89 | DRD2 (0.61) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1960292 | 0.89 | DRD2 (0.51) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1957424 | 0.87 | HTR6 (0.51) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1960126 | 0.86 | DRD2 (0.58) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1959549 | 0.86 | EPHX2 (0.55) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1960018 | 0.86 | HTR6 (0.48) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1960351 | 0.85 | DRD2 (0.57) | DRD2DRD3HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL1960794 | 0.84 | DRD2 (0.54) | DRD2DRD3HTR6HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207160-B2 | Tetrahydrobenzazepines and their use in he modulation of the dopamine D3 receptor | ABBOTT GMBH & CO. KG (DE) | 2012-06-26 | — | — | US | disclosed |
| EP-1694334-B1 | TETRAHYDROBENZAZEPINES AND THEIR USE IN THE MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| EP-2332543-A1 | Tetrahydrobenzazepines and their use in the modulation of the dopamine D3 receptor | Abbott GmbH & Co. KG (DE) | 2011-06-15 | — | — | EP | disclosed |
| US-20090105224-A1 | Tetrahydrobenzazepines and their use in the modulation of the dopamine d3 receptor | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20050137186-A1 | Tetrahydrobenzazepines and their use | ABBOTT GMBH & CO. KG. | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137186-A1 | Tetrahydrobenzazepines and their use | DRD3, ADRB3, AVPR1B | DRD2 9/4885DRD3 1/4885HTR6 115/4885 |
| US-20090105224-A1 | Tetrahydrobenzazepines and their use in the modulation of the dopamine d3 receptor | DRD3, DRD2, ADRB3 | DRD2 2/4885DRD3 1/4885HTR6 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.