Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 6/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 7/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.41 |
| ▸ | CDK7 | P50613 | 6/20 | 0.41 |
| ▸ | CCNH | P51946 | 5/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.41 |
| ▸ | CCNK | O75909 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17688405 | 0.87 | CCNT1 (0.44) | MERTKAXLTYRO3CDK2CCNA2 | |
| SCHEMBL19600377 | 0.83 | CCNA2 (0.41) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL19040155 | 0.77 | CDK9 (0.57) | MERTKAXLTYRO3CDK2CCNA2 | |
| SCHEMBL19600368 | 0.75 | CCNK (0.58) | CDK2CDK9CCNT1CDK7CCNH | |
| SCHEMBL17149748 | 0.73 | HTR6 (0.47) | CDK2CDK9CCNT1CDK7CCNH | |
| SCHEMBL19600365 | 0.73 | PDE5A (0.54) | PDE5ACYP1A2CYP3A4CYP2D6SCN8A | |
| SCHEMBL18069809 | 0.73 | CDK7 (0.48) | CDK2CDK9CCNT1CDK7CCNH | |
| SCHEMBL19040148 | 0.72 | CDK7 (0.71) | CDK2CDK9CCNT1CDK7CCNH | |
| SCHEMBL17696260 | 0.72 | CDK2 (0.40) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL19600360 | 0.71 | CDK7 (0.56) | CDK2CDK9CCNT1CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327496-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327496-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | MERTK 997/4885AXL 1159/4885TYRO3 2756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.