Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532001 | 0.81 | RAB9A (0.67) | NPC1RAB9AKMT2ACRBNHPGDS | |
| SCHEMBL20076245 | 0.80 | HPGDS (0.56) | HPGDSHDAC1HDAC10HDAC6KCNH2 | |
| Hydrochloric Acid SCHEMBL19283913 | 0.80 | KMT2A (0.66) | NPC1RAB9AKMT2ACRBNHPGDS | |
| SCHEMBL20423547 | 0.78 | CRBN (0.57) | NPC1RAB9AKMT2ACRBNHPGDS | |
| SCHEMBL386639 | 0.78 | P2RY12 (0.60) | NPC1RAB9AKMT2ACRBNHPGDS | |
| Hydrochloric Acid SCHEMBL25232851 | 0.77 | P2RY12 (0.59) | NPC1RAB9AKMT2ACRBNHPGDS | |
| Hydrochloric Acid SCHEMBL31570844 | 0.77 | P2RY12 (0.59) | NPC1RAB9AKMT2ACRBNHPGDS | |
| SCHEMBL5204132 | 0.77 | RAB9A (0.62) | NPC1RAB9AKMT2ACRBNHPGDS | |
| SCHEMBL4935859 | 0.76 | MAPT (0.51) | NPC1RAB9AKMT2AHPGDSHDAC1 | |
| SCHEMBL19601042 | 0.76 | HRH3 (0.45) | NPC1RAB9AKMT2ACRBNHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327469-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS, INC. | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327469-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | AR, MDM2, ESRRA | NPC1 1813/4885RAB9A 4010/4885KMT2A 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.